The film is a series of vignettes with Matthew Lillard’s sex advice is intercut within every couple segments. Mike (Ryan Pinkston) tries to impress his crush, Stacy (Cherilyn Wilson). Fred (Michael Cera) meets a girl (Joanna Garcia) online and they arrange for “menacing action”, only for Fred to break into the wrong apartment. The promiscuous Betty (Ashley Schneider) going to the “next level” (kinkier and more outrageous sexual adventures) with Chuck (Frankie Muniz), and later Fred. Justin (Andy Milonakis) buys a vibrating vagina and falls in love with it, all the time while crushing on another girl; the vibrating vagina has a personality of its own and commits “suicide” when Justin rejects it.
A Real Sex-esque skit where a girl admits to having sex with two black men on camera. Two guys, Barry and Leon (Kevin Hart and Jermaine Williams), create a woman on their computer, only for her to run wild.
Jessica (Rheagan Wallace), in an attempt to become horny, puts her vibrating cell phone in her vagina, only for it to fall in. Len (Ben Feldman) wakes up to find a girl and another guy (Jamie Kennedy) in his bed, and his parents home as well; the whole thing turns out to be a hidden camera show.
Sex education teacher Mr. Matthews (John P. Farley) teaches his class with no rules and a lot of embarrassment, usually centering on Mike. Ronny (Hank Harris), obsessed with Abraham Lincoln, creates a time machine and travels back in time to have sex with Lincoln (Ed Trotta).